Table 3.
Multivariable association of plasma CXCL12 with incident clinical events
| Failure event (total n = 3687) | Hazard Ratioa (95% CI) | P value | Hazard ratiob (95% CI) | P value |
|---|---|---|---|---|
| Probable Myocardial Infarction (n = 174) | ||||
| Model 1 | 1.37 (1.20, 1.56) | <0.001 | 2.01 (1.46, 2.75) | <0.001 |
| Model 2 | 1.34 (1.17, 1.53) | <0.001 | 1.89 (1.38, 2.59) | <0.001 |
| Model 3 | 1.26 (1.09, 1.45) | 0.001 | 1.69 (1.22, 2.33) | 0.001 |
| Model 4 | 1.19 (1.03, 1.39) | 0.02 | 1.52 (1.09, 2.13) | 0.01 |
| Death (n = 355) | ||||
| Model 1 | 1.36 (1.24, 1.49) | <0.001 | 1.90 (1.53, 2.37) | <0.001 |
| Model 2 | 1.32 (1.20, 1.44) | <0.001 | 1.77 (1.42, 2.21) | <0.001 |
| Model 3 | 1.20 (1.09, 1.33) | <0.001 | 1.51 (1.21, 1.88) | <0.001 |
| Model 4 | 1.10 (0.99, 1.22) | 0.09 | 1.28 (1.02, 1.61) | 0.04 |
| Any MI or death (n = 485) | ||||
| Model 1 | 1.37 (1.27, 1.49) | <0.001 | 1.90 (1.58, 2.30) | <0.001 |
| Model 2 | 1.34 (1.23, 1.45) | <0.001 | 1.78 (1.47, 2.15) | <0.001 |
| Model 3 | 1.23 (1.13, 1.34) | <0.001 | 1.53 (1.26, 1.85) | <0.001 |
| Model 4 | 1.13 (1.03, 1.24) | 0.01 | 1.30 (1.07, 1.59) | 0.008 |
Model 1: CXCL12 + demographic factors (age, sex, race).
Model 2: CXCL12 + demographic factors + traditional risk factors (diabetes, hypertension, hypercholesterolaemia, tobacco use, body mass index).
Model 3: CXCL12 + demographic factors + traditional risk factors + plasma inflammatory biomarkers (log transformed IL6, TNFα, and high-sensitivity C-reactive protein).
Model 4: CXCL12 + demographic factors + traditional risk factors + plasma inflammatory biomarkers + kidney function measures (CRIC-defined estimated glomerular filtration rate21 and log-transformed urinary albumin:creatinine ratio).
aFor one standard deviation increase in plasma CXCL12.
bFor plasma CXCL12 levels above the median cut point value of 2.432 ng/mL.