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. 2014 Jul 9;137(9):2578–2587. doi: 10.1093/brain/awu190

Figure 2.

Figure 2

Synaptic intensity and neuropathology measures by cognitive group. Synaptic ratios (A–C) and neuropathology measures (D–F) in the oldest-old. All three synaptic RIRs were reduced in dementia compared to normal with (A) synaptophysin and (B) SV2 and significantly different between the three cognitive groups, however, (C) VGLUT1 did not distinguish between CIND and dementia. No synaptic RIR distinguished normal from CIND. (D) Thal phase and scores were all increased in dementia compared to normal with (D) similar Thal phases reported for CIND and dementia, whereas (E) Braak stage and (F) cerebrovascular disease (CVD) pathologies, including hippocampal sclerosis, were significantly different between the three cognitive groups. Each measure is graphed with the first and third quartiles boxed with the median band dividing the box into darker upper and lighter lower ranges; a whisker line extends to the minimums and maximums; shaded diamonds represent the means.