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Tethering orientation of GMAP-210. The N-terminus has an ALPS motif that binds preferentially to curved membrane surfaces; the C-terminus has a GRAB domain that binds Arf1-GTP. The presence of ArfGAP1 on curved membranes keeps drives GMAP-210’s C terminus onto flattened membranes. Reprinted from Drin et al. (2008) with permission from AAAS.
