Table 2.
Serum folate (ng/mL) response to supplementation (mean (s.e.))
| Start | Middle | End | Response estimate at 12 weeks (95%CI) |
|
|---|---|---|---|---|
| DOSE 0 μg | 0 | 0 | ||
| Treatment Group A First period (n=42) |
13.3 (0.37) | 13.0 (0.45) | 13.0 (0.35) | −0.1 (−1.7, 1.5) |
| Treatment Group B (After washout) (n=34) |
11.6 (0.53) | 11.5 (0.73) | 11.8 (0.64) | 0.4 (−1.4, 2.2) |
| Dose 200μg | 200 | 200 | ||
| Treatment Group B (First period) (n=34) |
13.8 (0.46) | 14.9 (0.46) | 14.9 (0.38) | 1.0 (−0.8, 2.8) |
| Treatment Group C (First period) (n=34) |
14.3 (0.38) | 15.0 (0.33) | 14.5 (0.34) | 0.2 (−2.0, 2.4) |
| Treatment group A (After washout) (n=42) |
11.8 (0.42) | 15.5 (0.76) | 16.2 (1.34) | 4.4 (2.8, 6.0)b |
| Treatment Group D (After washout) (n=32) |
11.0 (0.49) | 13.7 (0.71) | 14.2 (0.72) | 3.4 (1.2, 5.6)b |
| Dose 400μg | 400 | 400 | ||
| Treatment Group D (First period) (n=32) |
13.9 (0.49) | 15.8 (0.87) | 16.1 (0.72) | 2.3 (0.1, 4.5)a |
| Treatment Group C (After washout) (n=34) |
11.3 (0.47) | 17.6 (2.04) | 20.0 (1.69) | 8.7 (6.7, 10.7)b |
a
Significant at p<0.05,
b
Significant at p<0.01