Table 5.
Dose effect estimates (mean (95% CI) on RBC folate by MTHFR C677T genotype and race
| 0* | 200* | 400* | |
|---|---|---|---|
|
677CC
(n = 58) |
7.3 (−33.9, 48.4) | 19.9 (−17.5, 57.3) | 72.2 (3.4, 141.0)a |
|
677CT
(n = 61) |
−46.0 (−83.0, −9.1)a | 10.9 (−23.7, 45.6) | 87.6 (24.3, 150.9)b |
|
677TT
(n = 23) |
11.6 (−38.8, 62.0) | −8.5 (−60.8, 43.8) | 246.6 (139.0, 354.1)b |
| African Americans | −3.6 (−45.4, 38.2) | 11.5 (−5.8, 58.9) | 105.6 (55.4, 155.8)b |
a
Significant at p<.05
b
Significant at p<.01
*
Randomization groups and time points are combined for each dose level.