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. 2014 Jul 22;42(14):9399–9409. doi: 10.1093/nar/gku632

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — (A) RdRp activity of HCV-NS5BΔ21 mutants relative to wild type in a cell-free enzyme assay. (B) Susceptibilities of the D559A and F162Y HCV-NS5BΔ21 RdRp mutants to quercetagetin relative to wild type in a cell-free enzyme assay. (C) Fold-increase in IC50s relative to wild type of mutants harboring the P495L, M423T, H95Q, M414T, S556A, C316Y, S96A and S282T substitutions, known to confer resistance to other NNI classes. Benzimidazole, a thumb-1 inhibitor, was used as a control. The mean ± SD of three independent experiments performed in duplicate is shown.