TABLE 1.

Summary of the sequence and activity of chimera library-Fc fusion variants

The potency and selectivity of chimera library-Fc fusion variants for Kv1.3 over Kv1.1 are shown. These variants include KV261-Fc and the parents OdK2-Fc and OsK1-Fc as well as their corresponding free peptides. The amino acid sequences of OdK2 and OsK1 peptides are aligned with disparate amino acids highlighted in gray. The variegated sequence of each variant with the change and position in amino acids are also indicated.