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Summary of KV261 and KV261 fusion proteins on Kv1.3 potency and selectivity in electrophysiology, inhibition of IL-2 secretion from stimulated human CD4+ T cells and induction of inflammatory TNFα from PBMC cultures.
TNFα induction is shown as -fold induction over basal levels in untreated PBMC cultures. Compounds showing low potency or TNFα induction are highlighted.
