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Alternative channel for the entry of substrates into the active site of R. capsulatus ALAS. A, alternative channel in the open and (B) closed conformations (PDB file 2BWN). This channel and the succinyl-CoA-specific channel are distinct. The N-terminal domain is shown in cyan, the catalytic domain in gray, and the C-terminal domain in magenta. The opposite monomer is shown in yellow. Succinyl-CoA is shown in stick representation.
