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Parameters of cardiac autonomic modulation before (gray) and after (black) ISO injections in older (12 months) conscious WT and R21C mice. A, HR; B, root mean square of successive R-R differences (RMSSD); C, total power (TP); D, LF. Data are given as mean ± S.E. Measurements were taken from 10 WT and 10 R21C mice. *, p < 0.05; †, p < 0.01 versus WT −ISO; ‡, p < 0.05; §, p < 0.01 versus WT −ISO. Error bars, S.E.
