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Inhibition of the Kir6.1/SUR2B currents by PPARβ/δ agonists. GW0742 (A) and GW501516 (B) are almost identical in their structures. They both inhibited the Kir6.1/SUR2B currents moderately. The IC50 was 80 μmol L-1 for GW0742 and 100μmol L-1 for GW501516, respectively (C).