Table 3. Adverse events (any grade; any cause) occurring in ≥20% of patients in either arm or grade ≥3 events (any cause) occurring in ≥3 patients.

Adverse event	Number of patients, n (%)
	Barasertib 1200 mg(n=48)				LDAC 400 mg(n=26)
	All grades	Grade 3	Grade 4	Grade 5	All grades	Grade 3	Grade 4	Grade 5
Stomatitis/mucositis	37 (77)	14 (29)	–	–	6 (23)	–	–	–
Febrile neutropenia	32 (67)	23 (48)	1 (2)	–	6 (23)	5 (19)	–	–
Diarrhea	24 (50)	2 (4)	–	–	3 (12)	–	–	–
Constipation	22 (46)	–	–	–	8 (31)	–	–	–
Nausea	21 (44)	1 (2)	–	–	10 (39)	–	–	–
Vomiting	16 (33)	–	–	–	5 (19)	–	–	–
Pyrexia	13 (27)	–	–	–	8 (31)	–	–	–
Pneumonia/lobar pneumonia	12 (25)	7 (15)*	–	4 (8)	2 (8)	1 (4)*	–	1 (4)
Alopecia	11 (23)	–	–	–	0	–	–	–
Epistaxis	11 (23)	–	–	–	6 (23)	–	–	–
Anemia	10 (21)	1 (2)	6 (13)	–	4 (15)	4 (15)	–	–
Decreased appetite	10 (21)	–	–	–	5 (19)	–	–	–
Insomnia	10 (21)	–	–	–	3 (12)	–	–	–
Rash	10 (21)	–	–	–	2 (8)	–	–	–
Fatigue	9 (19)	–	–	–	6 (23)	–	–	–
Thrombocytopenia	9 (19)	1 (2)	6 (13)	–	5 (19)	–	4 (15)	–
Back pain	8 (17)	–	–	–	2 (8)	–	–	–
Dyspnea	8 (17)	1 (2)	–	–	5 (19)	3 (12)	1 (4)	–
Hypokalemia	8 (17)	–	–	–	2 (8)	–	–	–
Asthenia	7 (15)	–	–	–	8 (31)	–	–	–
Neutropenia	7 (15)	4 (8)	3 (6)	–	2 (8)	–	2 (8)	–
Edema peripheral	7 (15)	–	–	–	7 (27)	–	–	–
Leukopenia	6 (13)	1 (2)	5 (10)	–	–	–	–	–
Cellulitis	4 (8)	4 (8)	–	–	–	–	–	–
Lymphopenia	4 (8)	1 (2)	3 (6)	–	–	–	–	–
Sepsis	4 (8)	3 (6)	1 (2)	–	–	–	–	1 (4)
Hyponatremia	3 (6)	3 (6)	–	–	1 (4)	1 (4)	–	–

^*Classified as pneumonia only. Stomatitis/mucositis includes oral pain, oropharyngeal pain, mouth ulceration, tongue ulceration, gingivitis, and aphthous stomatitis. Febrile neutropenia includes neutropenic infection, febrile bone marrow aplasia, and neutropenic sepsis