Table 3.

Least Squares Mean Change in Scale Score from Pretransplant Evaluation to Time Following Islet Transplant Alone (+/− Standard Error of Mean) for 27 Subjects Enrolled in the Long-Term Islet Transplant Study.

	Pretransplant Evaluation Scale Score	Change in Scale Score from Pretransplant Evaluation to…						Type 3 Test of Fixed Effects
		6 Months	1 Year	2 Year	3 Year	4 Year	5 Year	F Statistic	DF	p value
SF-36 Health Survey
Physical Functioning	91.88	1.08 ± 4.9	2.88 ± 4.5	−4.17 ± 4.5	−3.20 ± 4.6	−3.69 ± 4.5	−3.94 ± 4.5	1.19	6, 86	0.320
Role-Physical	76.45	−2.42 ± 9.6	5.86 ± 8.8	−8.62 ± 8.9	−12.54 ± 9.5	−5.34 ± 9.1	−0.48 ± 9.3	0.99	6, 72.4	0.436
Bodily Pain	78.47	7.58 ± 7.9	5.20 ± 7.2	−4.09 ± 7.4	3.82 ± 7.7	7.50 ± 7.6	2.68 ± 7.8	0.69	6, 77.7	0.657
General Health	64.14	5.83 ± 6.1	5.54 ± 5.6	−4.18 ± 5.8	−0.52 ± 6.0	2.65 ± 5.9	−1.84 ± 6.1	0.85	6, 75.9	0.537
Social Functioning	74.39	21.16 ± 10.6	12.44 ± 9.8	−15.21 ± 9.7	−5.42 ± 10.0	−10.68 ± 9.7	−7.75 ± 9.8	3.55	6, 67.9	0.004
Vitality	54.40	−3.44 ± 7.8	1.29 ± 7.2	−6.04 ± 7.3	−0.66 ± 7.6	−3.42 ± 7.5	−1.49 ± 7.6	0.26	6, 77.6	0.954
Role-Emotional	87.97	0.24 ± 7.1	5.86 ± 6.4	−5.46 ± 6.6	1.57 ± 7.0	−1.03 ± 6.7	2.11 ± 6.9	0.63	6, 76.8	0.702
Mental Health	62.84	3.89 ± 4.6	3.10 ± 4.2	−0.57 ± 4.3	3.83 ± 4.5	5.27 ± 4.5	4.95 ± 4.6	0.58	6, 75.6	0.743
Physical Component Summary	52.44	0.87 ± 2.9	1.80 ± 2.6	−2.32 ± 2.7	−2.30 ± 2.8	−0.23 ± 2.7	0.47 ± 2.8	0.71	6, 77.9	0.641
Mental Component Summary	45.11	3.03 ± 3.4	2.91 ± 3.1	−1.54 ± 3.2	2.55 ± 3.7	0.75 ± 3.2	1.41 ± 3.3	0.61	6, 75.8	0.719
Beck Depression Inventory	13.57	−5.55 ± 2.1	−7.80 ± 1.9	−7.07 ± 2.0	−5.76 ± 2.0	−4.48 ± 2.0	−3.77 ± 2.1	3.70	6, 73.5	0.003
EQ-5D VAS	68.28	9.73 ± 4.4	17.25 ± 4.0	13.35 ± 4.2	13.12 ± 4.3	10.00 ± 4.3	6.69 ± 4.4	3.84	6, 74	0.002
Diabetes Distress Scale
Emotional Burden	36.35	−6.09 ± 9.9	−0.24 ± 9.1	−7.21 ± 9.4	−6.64 ± 9.7	−6.56 ± 9.6	−5.61 ± 9.9	0.21	6, 75.6	0.971
Physician Related Distress	12.23	−5.76 ± 4.5	−3.38 ± 4.1	−6.54 ± 4.2	−6.17 ± 4.4	−4.15 ± 4.3	7.54 ± 4.4	0.67	6, 76.4	0.675
Regimen Related Distress	20.17	−4.21 ± 4.7	−4.80 ± 4.3	−3.09 ± 4.5	−5.47 ± 4.7	−5.88 ± 4.6	−5.49 ± 4.8	0.37	6, 71.4	0.894
Interpersonal Distress	14.86	−2.26 ± 5.9	3.42 ± 5.4	−0.19 ± 5.6	2.79 ± 5.8	−5.41 ± 5.7	−4.44 ± 5.9	0.83	6, 74.5	0.550
Hypoglycemia Fear Scale
Behavioral Subscale	47.94	−28.48 ± 6.2	−37.93 ± 5.7	−41.16 ± 5.8	−35.09 ± 6.2	−34.41 ± 6.0	−35.27 ± 6.1	10.42	6, 74.5	< 0.001
Worry Subscale	55.77	−41.94 ± 6.9	−46.13 ± 6.2	−46.91 ± 6.6	−39.49 ± 6.6	−37.52 ± 6.7	−37.16 ± 6.9	11.88	6, 71.4	< 0.001