Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
General reaction scheme for the hairpin ribozyme. The nucleophile is activated by a general or specific base. G8, in neutral form, stabilizes the activated nucleophile by dual hydrogen bond donation. A38 acts as a general acid to donate a proton to the leaving group facilitating cleavage.
