Extended Data Figure 2. Absence of enterocyte lipid accumulation and ER stress in Mttp^ΔIEC mice.

a, Absence of lipid accumulation in Mttp^ΔIEC mice as shown in representative haematoxylin and eosin and rare osmium tetroxide (arrows) staining in the caecum, proximal, and distal colon. Scale bar, 25 μm. b, Xbp1 splicing in small intestinal (SI) and colonic IECs of the indicated mice before (left) (n = 5 mice per group) and 6 h after rectal challenge with oxazolone (Ox., right) (n =5 mice per group). MODE-K cells were treated with either thapsigargin (Tg) or vehicle (DMSO) as positive and negative controls, respectively. Results representative of three independent experiments are shown.