Table 2.

Proposal for lines of research into patient safety in Telehealth systems, indicating the objectives and a list of research topics for each of them

Research lines/Analysis level	Objectives / Control parameters	Research Topics
Theory of CSTS Engineering in Telehealth	Scientific reference framework	CSTS Engineering methods and tools Dynamic Cognitive Networks Mobile Social Networks Resilience in Telehealth Systems
Patient Safety at the level of Healthcare Ecosystem in Society	Quality of Life (HLYa) Epidemiological data Macro-economic data	eHealth Governance Legal and organizational interoperability Patient empowerment policy Vigilance policy for patient safety in Telehealth Safety standards Certification Legal and ethical issues Holistic approach for patient safety
Patient Safety at the level of Healthcare Organization	Health outcomes Quality of Telehealth services Data of adverse events Economic data on Telehealth safety investments and operational costs. Costs related to adverse events Compliance with laws and regulations	Requirements Engineering for Patient Safety in Telehealth Implementation of vigilance policy Evaluation methodologies and tools for patient safety in Telehealth Organizational and semantic interoperability Integrated Models for patient safety at healthcare organizations
Patient Safety at Telehealth System level	Data of system performance Quality of Telehealth services Data on adverse events Micro-economic data on patient safety implementation and operation Compliance with standards and guidelines	Systems design for safety Telehealth systems standardisation Semantic interoperability Organizational interoperability Safety management in Telehealth Vigilance tools
Patient Safety at Entities sub-systems level	Adverse events detection and report Adherence of patients and professionals to protocols and guidelines Equipment and software compliance with safety and security standards Physical and environmental conditions at patient’s home Information on components change and performance	Secure patient and professional identification Tools and methods to measure and manage caregivers workload Decision support tools for healthcare professionals Accessibility and user interfaces Safety of personal devices and wearable Home devices interoperability Cloud safety for Telehealth applications Apps safety Non-invasive surveillance techniques Behaviour monitoring and data analysis Home systems reliability Energy issues Electromagnetic Compatibility at home
Methodologies and tools	Support technologies and techniques	Data mining and Analytics Geographical Information systems (GIS) Digital simulation Modeling languages Methods and tools for Telehealth system redesign

^a HLY Healthy Living Years