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. 2014 Aug 14;10(8):e1003802. doi: 10.1371/journal.pcbi.1003802

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© 2014 McHale, Lander

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A fraction s of stem cells divide symmetrically while the others divide asymmetrically. (B) Protection against the accumulation of two mutations. Lifetime is L = 10³ stem cell cycles and mutation rate is u₀ = 10⁻⁶. (C) Typical dynamics, with blow-up of the last few cell cycles (inset). Horizontal arrows indicate the mean time that a single-mutant lineage drifts before mutating, Eq. (S30), and the mean time until the production of the first single-mutant clone destined to mutate, (c.f. Eq. (5)). N = 10³ stem cells and mutation rates are u₀ = 10⁻⁶ and u₁ = 10⁻³ (cross in panel B). (D) Corresponding cumulative risk from simulation (symbols) and Eqs. (S55) and (S56) (lines).

Inline graphic — (A) A fraction s of stem cells divide symmetrically while the others divide asymmetrically. (B) Protection against the accumulation of two mutations. Lifetime is L = 10³ stem cell cycles and mutation rate is u₀ = 10⁻⁶. (C) Typical dynamics, with blow-up of the last few cell cycles (inset). Horizontal arrows indicate the mean time that a single-mutant lineage drifts before mutating, Eq. (S30), and the mean time until the production of the first single-mutant clone destined to mutate, (c.f. Eq. (5)). N = 10³ stem cells and mutation rates are u₀ = 10⁻⁶ and u₁ = 10⁻³ (cross in panel B). (D) Corresponding cumulative risk from simulation (symbols) and Eqs. (S55) and (S56) (lines).