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Wnt signaling pathway. Wnt signaling stimulates OB differentiation from MSCs. Blockade of this pathway through DKK1 inhibits OB formation. Wnt signaling upregulates RANKL expression from OB precursors resulting in increased osteoclastic activity and bone resorption. Activation of Wnt pathway increases OPG production from OB which in turn downregulates RANKL-driven osteoclastogenesis.67
