Table 1. Mathematical model of cell identity landscape.
Landscape Term: Index Notation | Landscape Term: Matrix Notation (dim.) | Biological Interpretation |
Total landscape. | ||
Produces cell basins of attraction. | ||
External control of individual genes, i.e. inducible expression. | ||
External control of specific cell basins, i.e. culturing conditions. | ||
Cell switching by signals, i.e. in vivo development. | ||
Number of TFs, labeled by , . In this paper N = 1337. | ||
Number of cell fates, labeled by , . In this paper . | ||
(×) | State () of TF. | |
(×) | State () of TF in cell fate . | |
(×) | Correlation between cell fate and . | |
(×) | Interaction strength between and . | |
(×) | External control of TF. | |
(×) | External control of cell fate. | |
(×) | Overlap of on cell fate . | |
(×) | Projection of on cell fate . | |
(×) | Predictivity of TF in cell fate . | |
(×) | Signal dependent coupling that drives cell fate to cell fate |
This table provides a summary of the landscape model and the biological interpretation of each term. The first column is written in index notation, while the second column is the same term in matrix notation with the dimension of the term given in parenthesis. If no dimension is listed, the term is a single number.