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. 2014 Aug 14;10(8):e1003734. doi: 10.1371/journal.pcbi.1003734

Table 1. Mathematical model of cell identity landscape.

Landscape Term: Index Notation Landscape Term: Matrix Notation (dim.) Biological Interpretation
Inline graphic Total landscape.
Inline graphic Inline graphic Produces cell basins of attraction.
Inline graphic Inline graphic External control of individual genes, i.e. inducible expression.
Inline graphic Inline graphic External control of specific cell basins, i.e. culturing conditions.
Inline graphic Inline graphic Cell switching by signals, i.e. in vivo development.
Inline graphic Number of TFs, labeled by Inline graphic, Inline graphic. In this paper N = 1337.
Inline graphic Number of cell fates, labeled by Inline graphic, Inline graphic. In this paper Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) State (Inline graphic) of Inline graphic TF.
Inline graphic Inline graphic (Inline graphic×Inline graphic) State (Inline graphic) of Inline graphic TF in cell fate Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Correlation between cell fate Inline graphic and Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Interaction strength between Inline graphic and Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) External control of Inline graphic TF.
Inline graphic Inline graphic (Inline graphic×Inline graphic) External control of Inline graphic cell fate.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Overlap of Inline graphic on cell fate Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Projection of Inline graphic on cell fate Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Predictivity of Inline graphic TF in cell fate Inline graphic.
Inline graphic Inline graphic (Inline graphic×Inline graphic) Signal dependent coupling that drives cell fate Inline graphic to cell fate Inline graphic

This table provides a summary of the landscape model and the biological interpretation of each term. The first column is written in index notation, while the second column is the same term in matrix notation with the dimension of the term given in parenthesis. If no dimension is listed, the term is a single number.