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. 2014 Jul 19;15:89. doi: 10.1186/1471-2202-15-89

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© Renda and Nashmi; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes in α4YFP nAChR expression in the medial habenula and the hippocampal medial perforant path. A) Montage of images of α4YFP nAChR expression in the medial perforant path and medial habenula (MHb) in a coronal mouse brain section. B) Chronic nicotine does not affect α4YFP nAChR expression in the MHb (14 ± 17% upregulation, p = 0.3, t-test). C) Chronic nicotine results in upregulation of α4YFP nAChRs in the medial perforant path (89 ± 16% upregulation, p = 0.001, Wilcoxon rank sum test) in mice.