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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Bone Miner Res. 2014 Jul;29(7):1681–1690. doi: 10.1002/jbmr.2193

Table 1.

Observed (O) Versus Expected (E) Underlying Causes of Death Among Olmsted County, Minnesota, Residents ≥ 50 Years of Age Following a Fracture (Fx) in 1989-91

All fractures
(N=1982)
Severe trauma Fx
(N=679)
Moderate trauma
Fx (N=1282)
Pathological Fx
(N=24)
Underlying Cause of Death O/E SMR (95% CI) O/E SMR (95% CI)
O/E SMR (95% CI) O/E SMR (95% CI)
Infectious and parasitic diseases 15/10 1.5 (0.8-2.5) 3/3.5 0.9 (0.2-2.5) 13/6.7 2.0 (1.04-3.3) 0/0.0 --
Neoplasms 214/206 1.0 (0.9-1.2) 67/81 0.8 (0.6-1.1) 129/126 1.0 (0.9-1.2) 22/0.6 39 (24-58)
Endocrine, nutritional and metabolic
 disease and immunity disorders
38/38 1.0 (0.7-1.4) 9/13 0.7 (0.3-1.3) 25/25 1.0 (0.6-1.5) 0/0.1 --
Disease of the blood and blood-forming organs 4/5.0 0.8 (0.2-2.0) 1/1.5 0.7 (0.02-3.7) 2/3.6 0.6 (0.1-2.0) 0/0 --
Mental disorders 101/48 2.1 (1.7-2.5) 20/14 1.5 (0.9-2.3) 78/35 2.2 (1.7-2.7) 0/0.2 --
Diseases of the nervous system
 and sense organs
69/49 1.4 (1.1-1.8) 18/17 1.1 (0.6-1.7) 51/33 1.5 (1.1-2.0) 0/0.2 --
Diseases of the circulatory system 466/419 1.1 (1.01-1.2) 120/129 0.9 (0.8-1.1) 346/294 1.2 (1.1-1.3) 2/1.4 1.4 (0.2-5.0)
Diseases of the respiratory system 141/104 1.4 (1.1-1.6) 34/35 1.0 (0.7-1.4) 109/71 1.5 (1.3-1.8) 0/0.3 --
Diseases of the digestive system 40/32 1.2 (0.9-1.7) 10/11 0.9 (0.5-1.7) 31/22 1.4 (0.96-2.0) 0/0.1 --
Diseases of the genitourinary system 32/23 1.4 (0.9-2.0) 5/7.4 0.7 (0.2-1.6) 29/16 1.8 (1.2-2.6) 0/0.1 --
Diseases of the skin and subcutaneous tissue 4/1.4 2.9 (0.8-7.4) 1/0.4 2.4 (0.1-13) 2/1.0 2.0 (0.2-7.4) 0/0 --
Diseases of the musculoskeletal system and
 connective tissue
22/9.0 2.4 (1.5-3.7) 2/2.9 0.7 (0.1-2.6) 21/6.2 3.4 (2.1-5.2) 0/0 --
Congenital anomalies 1/1.0 1.0 (0.03-5.6) 0/0.4 -- 1/0.6 1.6 (0.04-8.8) 0/0 --
Symptoms, signs, and ill-defined conditions 12/32 0.4 (0.2-0.7) 3/9.2 0.3 (0.1-0.95) 9/23 0.4 (0.2-0.8) 0/0.1 --
Injury and poisoning 77/30 2.6 (2.0-3.2) 22/10 2.1 (1.3-3.2) 56/20 2.8 (2.1-3.7) 0/0.1 --

Standardized mortality ratios (SMR) and 95% confidence intervals. Expected deaths by underlying cause are for the Minnesota population of comparable age and sex (http://wonder.cdc.gov/). Statistically significant (p < 0.05) associations are bolded.

Nine subjects with unknown underlying cause of death were excluded from this analysis. If a person had more than one fracture during the time period, (s)he could be included in more than one trauma category.No deaths were observed from “complications of pregnancy, childbirth, and the puerperium.”