Table 2.

Results of statistics for the effect of acute methamphetamine challenge on mouse behavior represented in Fig. 2. Three-way repeated-measures ANOVA was applied to all behavior categories except the “Running wheel” category, which was analyzed by two-way repeated-measures ANOVA. The F and P values are shown in upper and lower columns, respectively.

	Factor
Behavior category	Exposure to wheel (E) F value P value	Challenge (C)	Time (T)	E × C	E × T	C × T	E × C × T
Running wheel	N/A	2.590	10.367	N/A	N/A	1.218	N/A
	N/A	0.1249	< 0.0001	N/A	N/A	0.2976	N/A
Locomotion	21.572	0.008	99.755	3.179	6.085	13.362	0.727
	< 0.0001	0.9288	< 0.0001	0.0830	< 0.0001	< 0.0001	0.6496
Food access	18.755	12.174	31.311	0.129	1.907	5.913	1.812
	< 0.0001	< 0.01	< 0.0001	0.7213	0.0689	< 0.0001	0.0853
Food intake	0.642	2.323	20.569	2.933	2.990	1.961	0.627
	0.4282	0.1362	< 0.0001	0.0954	< 0.05	0.0609	0.7334
Water intake	6.506	1.269	22.437	0.014	1.507	2.826	0.602
	< 0.05	0.2674	< 0.0001	0.9077	0.1653	< 0.01	0.7544