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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Clin Pharmacokinet. 2014 Mar;53(3):247–259. doi: 10.1007/s40262-013-0109-y

Table 3.

Numerical Predictive Check of sitagliptin pharmacokinetic descriptors

PK descriptor Observeda Simulateda
Log AUC<24h (ng·h/mL) 9.23 (6.56–10.29) 8.79 (7.03–10.58)
Log AUC<48h (ng·h/mL) 9.73 (7.34–10.85) 9.41 (7.53–11.26)
Log AUC<72h (ng·h/mL) 9.86 (7.72–11.32) 9.79 (7.86–11.66)
Log AUC<96h (ng·h/mL) 10.05 (8.09–11.71) 10.05 (8.00–11.96)
Log Cmax(0-24h) (ng/mL) 7.50 (4.80–8.46) 6.55(4.83–8.32)
Log Cmax(24-48h) (ng/mL) 6.85 (3.69–8.43) 6.27 (2.56–8.26)
Log Cmax(48-72h) (ng/mL) 6.72 (3.83–7.92) 6.27 (2.56–8.28)
Log Cmax(72-96h) (ng/mL) 6.67 (3.25–8.48) 6.34 (2.58–8.30)
a

Values are expressed as median (2.5th–97.5th percentiles)

AUC<xh, area under the plasma drug concentration time curve from 0h to xh; Cmax(i-jh), maximum plasma concentration from ih to jh.