Table 2.
Comparison of pre-LTX and early post-LTX variables between trajectory groups
| Pre- and early post-LTX variables | Low depression | Increasing depression | High depression | Test statistica, p-Value |
|---|---|---|---|---|
| Demographic | ||||
| Age, mean (SD) | 52 (8) | 48 (7) | 48 (8) | 5.9, 0.003 |
| Gender (% male) | 87 | 73 | 87 | ns |
| Race (% white) | 96 | 95 | 94 | ns |
| Married or had partner (% yes) | 61 | 44 | 36 | 7.5, 0.02 |
| Education (% beyond HS) | 53 | 40 | 43 | ns |
| Psychosocial | ||||
| Alcohol dependence dx (% yes) | 72 | 73 | 87 | ns |
| Family hx alcoholism (% yes) | 62 | 58 | 72 | ns |
| Prior hx of depression (% yes) | 12 | 32 | 26 | 0.046* |
| Other substance use (% yes) | 28 | 42 | 61 | 11, 0.004 |
| Years of heavy drinking, mean (SD) | 22 (9) | 18 (8) | 18 (9) | 3.2, 0.04 |
| Length of sobriety, months (SD) | 41 (47) | 39 (43) | 41 (45) | ns |
| Alcohol amount consumed in first year, mean (SD)b | 8 (38) | 12 (42) | 6 (17) | ns |
| Medical | ||||
| HCV infection (% yes) | 38 | 54 | 65 | 7.7, 0.02 |
| HCC (% yes) | 16 | 7 | 19 | ns |
| MELD, mean (SD) | 17 (7) | 17 (7) | 16 (8) | ns |
| Length of hospital stay, m days (SD) | 24 (24) | 25 (23) | 24 (24) | ns |
| ICU length of stay, m days (SD) | 14 (21) | 15 (18) | 17 (24) | ns |
| Donor age, mean years (SD) | 46 (17) | 47 (15) | 41 (18) | ns |
| Charlson comorbidity index at 1 year, m (SD) | 6.8 (1.2) | 7.2 (1.7) | 7.4 (1.4) | ns |
| Inpatient admissions within first year, m (SD) | 2.3 (2) | 1.9 (1.7) | 2.7 (2.8) | ns |
| Transplant clinic visits within first year, m (SD) | 30 (12) | 31 (12) | 26 (14) | ns |
*
Exact p-value is reported because the number of cases is small (2-sided Fisher’s exact p).
a
χ2(2) for dichotomous variables, F (2,167) for continuous variables.
b
For purposes of comparison between types of alcohol consumed, alcohol consumption was reported in standard alcohol drink units (i.e. one 12-ounce beer, 5–6 ounces of wine or a 1-ounce ‘shot’ of hard liquor). Untransformed data are presented for clarity.