Table 4.

Comparison of outcomes between the three BDI trajectory groups

Outcomes	Low depression	Increasing depression	High depression	Exact p*
≥20% of biopsies with steatohepatitisa	8%, n = 7	8%, n = 3	13%, n = 4	p = 0.69
≥20% of biopsies with acute rejectionb	31%, n = 27	36%, n = 14	27%, n = 8	p = 0.73
Graft failure	37%, n = 10	55%, n = 11	31%, n = 5	p = 0.32
≥ 50% GGTP values abnormal	68% n = 65	85% n = 35	87% n = 27	p = 0.03
≥ 50% AST values abnormal	38% n = 36	51% n = 21	36% n = 11	p = 0.28
≥ 50% ALT values abnormal	58% n = 55	73% n = 30	74% n = 23	p = 0.13
≥ 50% creatinine values abnormal	44% n = 42	49% n = 20	48% n = 15	p = .86
Causes of death	N = 27c	N = 20	N = 16
Alcoholic liver disease	7%, n = 2	5%, n = 1	6%, n = 1	p = 1.0
Recurrent HCV	22%, n = 6	35%, n = 7	25%, n = 4	p = 0.67
Other causes of liver failured	7%, n = 2	15%, n = 3	12%, n = 2	p = 0.69
Malignancye	37%, n = 10	5%, n = 1	6%, n = 1	p = 0.009
Cardiac eventsf	4%, n = 1	10%, n = 2	12%, n = 2	p = 0.59
Infection or sepsis	7%, n = 2	15%, n = 3	19%, n = 3	p = 0.50
Unknown	7%, n = 2	5%, n = 1	12%, n = 2	p = 0.71
Accident/trauma	7%, n = 2	5%, n = 1	0%	p = 0.78
Other	4%, n = 1	5%, n = 1	6%, n = 1	p = 1.00

^*Exact p-values are reported because the numbers of cases are small (2-sided Fisher’s exact p).

^aTen participants did not get biopsies.

^bRejection Activity Index score ≥ 3 on biopsy.

^cTotal number adds to more than 27 as two persons died of a combination of recurrent HCV and alcohol related liver disease.

^dIncludes portal vein thrombosis, hepatic artery thrombosis, acute/chronic rejection, infarction.

^eIncludes hepatocellular carcinoma, lung and skin.

^fIncludes myocardial infarction, heart failure, arrhythmia.