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. Author manuscript; available in PMC: 2014 Aug 14.
Published in final edited form as: J Cyst Fibros. 2008 Nov 20;8(1):1–8. doi: 10.1016/j.jcf.2008.10.002

Figure 1. IL-17-induced neutrophil recruitment in CF.

Figure 1

Production of Interleukin (IL)-6, transforming growth factor (TGF)-β and IL-23 by airway dendritic cells (DC) following activation by bacterial pathogens promotes Th17 cell differentiation. The release of IL-17A and IL-17F from these cells acts on airway epithelial cells to release neutrophil chemokines IL-6. IL-8 and growth related oncogene (GRO)-α. ICAM-1, intracellular adhesion molecule-1; MPO, myeloperoxidase; MMP, matrix metalloprotease.

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