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. 2014 Aug 14;10(8):e1003783. doi: 10.1371/journal.pcbi.1003783

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© 2014 Cao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — represents cytoplasmic concentration, excluding a small local (whose concentration is denoted by ) close to the release site (i.e., an cluster). Upon coordinated openings of the , SR () is first released into the local domain () to cause a rapid increase in . High local then diffuses to the rest of the cytoplasm (), and is eventually pumped back to the SR ().

represents cytoplasmic concentration, excluding a small local (whose concentration is denoted by ) close to the release site (i.e., an cluster). Upon coordinated openings of the , SR () is first released into the local domain () to cause a rapid increase in . High local then diffuses to the rest of the cytoplasm (), and is eventually pumped back to the SR ().