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. 2014 Aug 14;9(8):e103109. doi: 10.1371/journal.pone.0103109

Figure 2. Chemosensitizing effects of simultaneous ER-stress induction and AKT suppression.

Figure 2

(A). Simultaneous induction of ER-stress by Thapsigargin (Tg) and suppression of AKT by an Akt-inhibitor (Akt-I) may render cancer cells susceptible to the cytotoxic actions of chemotherapy. (B). Cytotoxic effects of DTX, alone or in combination with Tg and/or Akt-I, on C4-2B cell viability. Coexposure to Tg (25 nM) and Akt-I (2.5 µM) enhanced DTX (10 nM) induced cytotoxicity at 72 hrs post exposure (n = 3). Error bars represent ±SEM values and significant differences are shown as P-values (***, p<0.0005).