Table 2. Comparison of genome-wide torsion studies (“supercoilinomics”).
| Bermudez et al. | Naughton et al. | Kouzine et al. | Teves and Henikoff | |
|---|---|---|---|---|
| Organism | Yeast | Human | Human | Drosophilia |
| Substrate | TMP | bTMP | TMP | TMP |
| Enrichment Method | Heat denuration and Exo I digestion | Streptavidin pulldown | Heat-glyoxal denaturation and gel electrophoresis | Heat denuration and Exo I digestion |
| Platform | Microarray | Microarray | Microarray | PE sequencing |
| Assay Resolution | 2 kb | Unknown | 250 bp | Nucleotide |
| Effective Resolution | 2 kb | ~10kb | ~1–5 kb | 150 bp |