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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Invest Dermatol. 2014 May 1;134(9):2315–2320. doi: 10.1038/jid.2014.167

Figure 1. dsRNA from UV-damaged keratinocytes activates TLR3.

Figure 1

Excessive UV exposure causes necrosis in a population of keratinocytes in the epidermis. Loss of membrane integrity in these necrotic keratinocytes causes cellular contents to be spilled into extracellular space. DAMPs released by necrotic keratinocytes are then taken up by neighboring, healthy keratinocytes. dsRNA from necrotic keratinocytes is trafficked to the endosome where it activates TLR3. Downstream signaling leads to inflammation and increases in lipid biosynthesis, metabolism, and transport.