Table 2. The frequencies of the LEPR gene Lys109Arg, Gln223Arg and Lys656Asn polymorphisms genotypes.
| Genotype (frequency, %) | P-value | Allele (frequency, %) | P-valuea | ||||
|---|---|---|---|---|---|---|---|
|
Lys109Arg | |||||||
| |
GG |
AG |
AA |
|
G |
A |
|
| Case | 547 (67.1) | 246 (30.2) | 22 (2.7) | 0.601 | 1340 (82.2) | 290 (17.8) | 0.486 |
| Control |
323 (65.9) |
149 (30.4) |
18 (3.7) |
|
795 (81.1) |
185 (18.9) |
|
|
Gln223Arg | |||||||
| Case | 608 (75.2) | 192 (23.8) | 8 (1.0) | 0.041 | 1408 (87.1) | 208 (12.9) | 0.189 |
| Control |
360 (73.5) |
116 (23.7) |
14 (2.9) |
|
836 (85.3) |
144 (14.7) |
|
|
Lys656Asn | |||||||
| |
GG |
GC |
CC |
|
G |
C |
|
| Case | 684 (86.6) | 104 (13.2) | 2 (0.3) | 0.233 | 1472 (93.2) | 108 (6.8) | 0.098 |
| Control | 424 (89.8) | 47 (10.0) | 1 (0.2) | 895 (94.8) | 49 (5.2) | ||
a
P-value of the comparison of allelic frequencies. P-value <0.05 is provided in bold to emphasize its significance.