Table 5. Haplotype analyses of the LEPR gene polymorphisms in hypertension and control subjects.
| Haplotype frequency | |||||||
|---|---|---|---|---|---|---|---|
|
Lys109Arg |
Gln223Arg |
Cases |
Controls |
HS test P-valuea |
OR (95% CI)a |
P-valueb |
OR (95% CI)b |
| G | G | 0.808 | 0.784 | 0.132 | 1.162 (0.956–1.413) | — | — |
| A | A | 0.114 | 0.120 | 0.647 | 0.944 (0.738–1.207) | 0.519 | 1.085 (0.847–1.390) |
| A | G | 0.065 | 0.069 | 0.660 | 0.931 (0.679–1.278) | 0.550 | 1.102 (0.802–1.514) |
| G | A | 0.014 | 0.028 | 0.012 | 0.482 (0.273–0.850) | 0.010 | 0.474 (0.269–0.837) |
Abbreviations: CI, confidence interval; HS test, haplotype-specific testing; OR, odds ratio.
All haplotypes with frequency >1% detected in the haplotype analyses are shown in the table.
a
P-values and OR values derived from comparing of a specific haplotype with the other three.
b
P-values and OR values derived from comparing each haplotype with the baseline haplotype (G-G). P-values <0.05 are provided in bold to emphasize their significance.