Table 1.
Effect of the sex of the T cell donor on the number of CD4+, CD4+FOXP3+ Treg and CD8+ infiltrating T cells in PVAT and kidney tissue sections from male ag1−/−-M mice after adoptive transfer and Ang II infusion
| T cell Subset | WT-M + Veh (n=5) |
WT-M + Ang II (n=6) |
CD3M→Rag1−/−-M + Ang II (n=7) |
CD3F →Rag1−/−-M + Ang II (n=7) |
|---|---|---|---|---|
| PVAT | ||||
| CD4+ | 2.5 ± 0.4 | 20 ± 4† | 6.7 ± 2 | 14 ± 2* |
| CD4+FOXP3+ | 3.5 ± 0.4 | 11 ± 1† | 10 ± 1 | 9.0 ± 1 |
| CD8+ | 2.8 ± 0.8 | 22 ± 4† | 6.6 ± 2 | 9.3 ± 1* |
| Kidney | ||||
| CD4+ | 5.3 ± 1 | 14 ± 1† | 6.9 ± 1 | 6.4 ± 0.9 |
| CD4+FOXP3+ | 4.0 ± 1 | 12 ± 1 | 7.7 ± 1 | 7.4 ± 1 |
| CD8+ | 7.0 ± 1 | 19 ± 3† | 9.2 ± 0.4 | 11 ± 1 |
The data were analyzed by t-test;
*
p<0.05 compared to CD3M→Rag1−/−-M + Ang II, same tissue and genotype;
†
p<0.05 compared to vehicle (Veh), same tissue and genotype