Table 1.

Baseline demographic and clinical data for subjects.

Group	All subjects	CN	MCI	AD dementia
N	402	104	203	95
Age (years)	75.4±6.7	75.9±4.8	75.0.±7.2	75.6±7.4
Sex (% male)	63.9	62.0	67.5	59.0
Education (years)	15.5±3.1‡	15.9±3.1	15.8±2.9	14.6±3.3
AMNART IQ	117.5±11.5††	120.7±11.29	117.2 ±11.0	114.4±11.9
Duration of AD dementia symptoms (years)	-	0.0±0.1	0.0±0.1	3.7±2.4
APOE4 (% non-carrier/heterozygous carrier/homozygous carrier)	51.0/38.3/10.7†	75.0/23.1/1.9	46.8/40.4/12.8	33.7/50.5/15.8
MMSE	26.8±2.6*	29.0±1.1	27.2±1.7	23.5±2.1
RAVLT Total Learning	32.2±11.1*	42.2±9.8	31.4±9.1	22.9±6.9
Digit Symbol	36.5±13.0*	44.5±10.4	37.4±10.9	26.0±12.4
NPI-Q Apathy (% present)	0.3±0.6 (18.2)**	0.02±0.1 (1.9)	0.2±0.6 (15.3)	0.6±0.8 (42.1)
NPI-Q Depression (% present)	0.2±0.5 (18.7)‡	0.1±0.3 (6.7)	0.2±0.5 (17.2)	0.4±0.7 (34.7)
FAQ	5.0±6.6*	0.2±0.8	3.4±3.9	13.6±6.7

AD (Alzheimer's disease), AMNART IQ (American National Adult Reading Test intelligence quotient), APOE4 (Apolipoprotein E ε4), CN (clinically normal elderly), FAQ (Functional Activities Questionnaire), MCI (mild cognitive impairment), MMSE (Mini-Mental State Examination), NPI-Q (Neuropsychiatric Inventory brief questionnaire form), RAVLT (Rey Auditory Verbal Learning Test).

All values (except n, sex, APOE4) represent mean ± standard deviation.

^*p<0.0001 for CN vs. MCI, CN vs. AD and MCI vs. AD.

^**p<0.05 for CN vs. MCI, CN vs. AD and MCI vs. AD.

^†p<0.0001 for CN vs. MCI and CN vs. AD.

^††p<0.05 for CN vs. MCI and CN vs. AD.

^‡p<0.05 for CN vs. AD and MCI vs. AD.