Table 2.
Cross-sectional general linear model of the association of FAQ to regional FDG metabolism and covariates.
| Model: R2=0.71, p<0.0001 | ||||||
|---|---|---|---|---|---|---|
| Predictor | β | 95% CI for β | p | % Variance Accounted for | ||
| Total | Partial | |||||
| Baseline Diagnosis | AD | 60.4 | 44.92, 75.89 | <0.0001 | 5.2 | 14.7 |
| MCI | 19.1 | 5.09, 33.03 | ||||
| CN | 0 | |||||
| Posterior cingulate | 2.99 | -5.93, 11.91 | 0.0004 | 0.9 | 2.9 | |
| Parahippocampus | 3.37 | -11.58, 18.32 | 0.009 | 0.5 | 0.5 | |
| Posterior cingulate × Diagnosis | AD | -28.62 | -41.18, -16.07 | <0.0001 | 1.5 | 4.6 |
| MCI | -8.64 | -19.05, 1.77 | ||||
| CN | 0 | |||||
| Parahippocampus × Diagnosis | AD | -31.91 | -49.77, -14.04 | 0.0008 | 0.9 | 3.0 |
| MCI | -10.32 | -27.19, 6.54 | ||||
| CN | 0 | |||||
| Middle frontal | -12.81 | -21.32, -4.30 | 0.003 | 0.6 | 1.9 | |
| Orbitofrontal | -13.86 | -24.28, -3.43 | 0.009 | 0.4 | 1.4 | |
| Frontal pole | 16.34 | 4.38, 28.29 | 0.008 | 0.5 | 1.5 | |
| Digit Symbol | -0.04 | -0.08, -0.01 | 0.02 | 0.3 | 1.1 | |
| NPI-Q apathy | 1.68 | 1.02, 2.33 | <0.0001 | 1.8 | 5.7 | |
AD (Alzheimer's disease), β (partial unstandardized regression coefficient estimate), CI (confidence interval), CN (clinically normal elderly), MCI (mild cognitive impairment), NPI-Q (Neuropsychiatric Inventory brief questionnaire form), ‘×’ indicates an interaction. CN was used as a reference group in predictors including diagnosis.
“%Variance Total” represents percent of total variance of FAQ uniquely associated with the indicated predictor (unbiased population estimate), “%Variance Partial” represents percent of variance of FAQ with portion associated with other predictors pre-removed, which is uniquely associated with the indicated predictor (unbiased population estimate).