Table 3.

Mixed effects model of longitudinal FAQ association with baseline regional FDG metabolism and covariates.

Model: R2=0.75 for fixed effects, p<0.0001; R2=0.95 including random terms, p<0.0001
Predictor		β	95% CI for β	p
Posterior cingulate gyrus		2.00	-3.00, 7.00	0.43
Middle frontal gyrus		1.66	-4.55, 7.86	0.60
Orbitofrontal cortex		-5.72	-12.6, 1.15	0.10
Time in study (years)		5.58	0.95, 10.2	0.004
Posterior cingulate gyrus × time		-4.80	-8.10, -1.51	0.004
Middle frontal gyrus × time		-7.67	-11.95, -3.39	0.0005
Orbitofrontal cortex × time		8.42	3.64, 13.20	0.0006
Baseline FAQ		0.79	0.71, 0.87	<0.0001
RAVLT total learning		-0.05	-0.09, -0.02	0.005
NPI-Q apathy		0.60	0.01, 1.18	0.05
APOE4		0.52	0.05, 1.00	0.03
Sex	Female	0.67	0.02, 1.33	0.04
	Male	0
Baseline Diagnosis	AD	2.32	0.69, 3.96	<0.0001
	MCI	-0.81	-1.84, 0.21
	CN	0
Baseline Diagnosis × time	AD	1.57	0.68, 2.47	<0.0001
	MCI	1.64	1.04, 2.25
	CN	0

AD (Alzheimer's disease), APOE4 (Apolipoprotein E ε4), β (partial unstandardized regression coefficient estimate), CI (confidence interval), CN (clinically normal elderly), FAQ (Functional Activities Questionnaire), MCI (mild cognitive impairment), NPI-Q (Neuropsychiatric Inventory brief questionnaire form), RAVLT (Rey Auditory Verbal Learning Test). ‘×’ indicates an interaction.

CN and male sex were used as reference groups in predictors including diagnosis or sex.