Figure 4. PDGF-BB did not accelerate wound closure, contraction or reepithelialization in the mouse splinted full thickness dermal wound model.

Percentage wound closure (A) and contraction (B) as mean ± SEM in full thickness splinted wounds of db/db mice treated with 0.01% PDGF-BB or vehicle control. Wound area was measured from photographs taken immediately after wounding, and then the area including open wound plus new epithelium was measured from photographs taken day 2, 4, 6, 8, 10, and 11. Percentage wound contraction and closure was calculated as described in methods. Epithelial gap (C) and reepithelialization (D) were measured by histopathological evaluation. All data were expressed as mean ± SEM. No significant differences between groups were found in any comparision.