Figure 1. Change of the APC sensitivity ratio during the study period.

Box-whisker plots show the ratio [ETP_+APC/ETP_−APC] at visits 1–4. The center horizontal solid line is drawn at the median. Top and bottom edges of the boxes are located at the sample 75^th and 25^th percentiles. Top and bottom of the whiskers are located at the 90^th and 10^th percentiles. Each outlier is shown. P values indicate the changes of visits 2–4 compared to visit 1.