Table 1. Cycling hypoxia-responsive genes in different cell lines (FDR adjusted p<0.05; the highest fold change between cycling vs. chronic and/or chronic vs. cycling hypoxia).
| SK-OV-3 | PC-3 | WM793B | |||||||||
| Genesymbol | GeneID | Cyclingvs.control(foldchange) | Chronicvs.control(foldchange) | Genesymbol | GeneID | Cyclingvs.control(foldchange) | Chronicvs.control(foldchange) | Genesymbol | GeneID | Cyclingvs. control(foldchange) | Chronicvs. control(foldchange) |
| E2F7 | 228033_at | +10.2 | +5.7 | DHRS9 | 224009_x_at | +17.5 | +7.4 | TRIM73 | 1554250_s_at | +3.3 | +2.0 |
| IL8 | 211506_s_at | +9.13 | +1.8 | CEACAM5 | 201884_at | +9.7 | +6.8 | C17orf91 | 214696_at | +2.4 | –1.1 |
| THBS1 | 201109_s_at | +8.9 | +1,8 | PDK3 | 206348_s_at | +6.6 | +4.2 | RASGRP1 | 205590_at | –2.0 | +1.8 |
| KITLG | 226534_at | +9.6 | +4.0 | SERPINB2 | 204614_at | +5.9 | +2.0 | FAM13A | 217047_s_at | –2.0 | 1.0 |
| FAM83D | 225687_at | +6.3 | +3.0 | IL1RN | 212657_s_at | +5.3 | +3.0 | ARHGAP24 | 223422_s_at | –2.0 | 1.0 |
| STK17A | 202695_s_at | +5.7 | +2.2 | SHANK2 | 243681_at | +4.4 | +0.9 | BIRC3 | 210538_s_at | –2.1 | +1.1 |
| HBEGF | 38037_at | +5.7 | 1.0 | ST6GAL2 | 228821_at | +4.05 | +2.6 | TNFAIP3 | 202643_s_at | –2.1 | +1.4 |
| IRAK2 | 231779_at | +5.3 | +2.2 | CEACAM6 | 211657_at | +3.5 | +1.9 | MTSS1 | 203037_s_at | –2.1 | –1.3 |
| PHLDB2 | 238419_at | +5.2 | +2.4 | HBEGF* | 38037_at | +3.2 | +2.3 | UBASH3B | 238587_at | –2.1 | –1.3 |
| MKI67 | 212020_s_at | +5.05 | +2.9 | EDN1 | 222802_at | +3.0 | +2.0 | TNFAIP3 | 202644_s_at | –2.1 | 1.0 |
| EPHA2 | 203499_at | +4.4 | +1.8 | AREGB | 1557285_at | +3.0 | +1.4 | ABTB2 | 213497_at | –2.2 | –1.2 |
| PLAU | 211668_s_at | +4.2 | +2.1 | CBLB | 227900_at | +3.0 | +1.4 | IRAK2 | 231779_at | –2.4 | –1.3 |
| DUSP6 | 208893_s_at | +3.3 | –1.4 | AREGB | 1557285_at | +2.9 | +1.4 | LINGO2 | 232720_at | –2.4 | –1.5 |
| AREG | 205239_at | +2.7 | –6.5 | ARL14 | 220468_at | +2.9 | +1.2 | NFKBIZ | 223218_s_at | –2.7 | –1.4 |
| IL1A | 210118_s_at | +2.7 | –1.6 | PLAU | 211668_s_at | +2.4 | +1.4 | CXCL3 | 207850_at | –2.9 | –1.2 |
| IL6 | 205207_at | +2.5 | –1.7 | AREG | 205239_at | +2.4 | +1.1 | ZMYND8 | 209049_s_at | –3.3 | –2.1 |
| CXCL2 | 209774_x_at | +2.3 | –3.9 | ZNF846 | 1569157_s_at | +2.3 | 1.0 | MIRHG2 | 229437_at | –4.4 | –2.8 |
| EREG | 205767_at | +2.15 | -12.7 | HSPA6 | 213418_at | –3.6 | –1.5 | PDE4B | 203708_at | –4.5 | –1.9 |
| IGFBP1 | 1558605_at | –3.4 | +1.7 | PSMB4 | 228204_at | –4.7 | +1.8 | CXCL2 | 209774_x_at | –4.5 | –1.3 |
| INSIG1 | 201626_at | –3.9 | +1.9 | RPLP2 | 200908_s_at | –6.0 | +1.1 | ACSL6 | 213683_at | –6.8 | –4.4 |
The genes in bold have been chosen for qRT-PCR validation. The gene marked with * was marginal regarding the criteria described in the text.