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Cells with low Snail maintain an epithelial morphology. During cancer progression, the expression of Snail increases, which promotes the nuclear localization of p-ERK2 isoform. This leads to EMT characterized by decreased E-cadherin, increased vimentin, decreased cell adhesion and increased cell migration. By a positive feedback loop, p-ERK can increase Snail expression. This leads to tumors with high levels of Snail and a mesenchymal morphology.
