Table 2. The 22 Rhythmic Genes Highly Expressed in Heart vs. 96 Murine Tissues.
Gene Symbol | Heart-enriched (fold change) | JTK p-value | JTK q-value | JTK Period | JTK Phase |
Rhobtb1 | 12.8 | 1.229E-10 | 8.741E-07 | 24 | 19 |
Tcap | 10.1 | 1.053E-08 | 1.628E-05 | 24 | 16 |
Mlf1 | 9.2 | 5.973E-07 | 2.124E-04 | 24 | 17.5 |
Mylk4 | 7.5 | 2.364E-07 | 1.274E-04 | 24 | 18 |
Ccdc141 | 6.3 | 3.222E-04 | 1.776E-02 | 24 | 16 |
Kcnh2 | 6.1 | 2.364E-07 | 1.274E-04 | 24 | 18 |
Sh3rf2 | 5.2 | 5.841E-04 | 2.683E-02 | 24 | 17 |
Gpcpd1 | 4.5 | 3.781E-07 | 1.660E-04 | 23 | 18 |
Calcoco1 | 4.2 | 7.792E-04 | 3.326E-02 | 24 | 18 |
Ppip5k2 | 4.0 | 1.257E-04 | 9.066E-03 | 24 | 19 |
Vps25 | 3.9 | 3.244E-05 | 3.516E-03 | 24 | 18 |
Raph1 | 3.9 | 5.841E-04 | 2.683E-02 | 24 | 20 |
Nfia | 3.6 | 3.244E-05 | 3.516E-03 | 24 | 16 |
Socs2 | 3.5 | 1.732E-04 | 1.153E-02 | 24 | 18 |
Cygb | 3.3 | 1.080E-05 | 1.685E-03 | 24 | 17 |
Klf9 | 3.2 | 6.482E-05 | 5.748E-03 | 24 | 16 |
Usp2 | 2.6 | 9.323E-07 | 2.934E-04 | 24 | 18 |
Dusp7 | 2.4 | 1.732E-04 | 1.153E-02 | 25 | 19 |
1810013L24Rik | 2.3 | 3.222E-04 | 1.776E-02 | 23 | 18 |
Acer2 | 1.9 | 4.603E-05 | 4.547E-03 | 24 | 18 |
Slco5a1 | 1.8 | 3.781E-07 | 1.660E-04 | 24 | 20 |
Timp3 | 1.6 | 9.430E-10 | 3.353E-06 | 23 | 20 |
Heart-enriched (fold change) values are derived from the BioGPS website (http://biogps.org/) [28] and embedded GeneAtlas MOE430 gcrma gene expression activity chart [29], which were used to interrogate cardiac expression of genes of interest. Statistical values are from CircaDB and the JTK_Cycle algorithm, Mouse 1.OST Heart (Affymetrix) microarrays [19]–[22].