Figure 11. Kaplan-Meier curves depicting survival rates in mice immunised with single peptides and infected with F. hepatica metacercariae.

A). Mice immunised with single peptides containing B-epitopes. B). Mice immunised with single peptides containing T-epitopes. Survival rates of mice belonging to both untreated and infected controls are also represented. Human endpoint was established when an indicator of severe pain, excessive distress, suffering or an impending death was observed in any of the animals and then euthanised with an intraperitoneal injection of pentobarbital at 60 mg/kg using 30 g needles.