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. 2014 Aug 14;8(8):e3079. doi: 10.1371/journal.pntd.0003079

Figure 1. Effect of NO on the anti-B. pseudomallei activity of β-lactam antibiotics.

Figure 1

Growth of log and stationary phase B. pseudomallei in LBG broth 2.5 h after culture (A). B. pseudomallei grown to log (log) or stationary (sta) phase were treated for 2.5 h with increasing concentrations of imipenem (B). Panel C shows the effect of 100 µM spermine NONOate (sNO) on the anti-B. pseudomallei activity of 25 µg/ml imipenem (IM). The protection afforded by 2.5 mM DETA NONOate (dNO) against 64 µg/ml ceftazidime (CT) is shown in D. The data are the mean ± SD from 3 observations collected in 2 separate days. p<0.001 compared to the antibiotic-treated group.