Table 1. Positively selected genes bearing transposon mutations that increase the tolerance of B. pseudomallei to imipemen.
Genes | Description | Fold change1 |
BPSL0453 | cytochrome c oxidase | 3.25 |
BPSL3181 | cytochrome c | 4.37 |
moaC | molybdenum cofactor biosynthesis protein | 6.06 |
mogA | molybdenum cofactor biosynthesis protein | 3.03 |
oxa | β-lactamase precursor | 8.09 |
obgE | GTPase | 6.67 |
amn | AMP nucleosidase | 3.10 |
gmk | guanylate kinase | 7.68 |
glnB1 | nitrogen regulatory protein P-II 1 | 4.59 |
trmB | tRNA (guanine-N-(7)-)methyltransferase | 4.51 |
clpA | ATP-dependent Clp protease | 3.53 |
BPSS1056 | CopG Family transcriptional regulator | 8.12 |
BPSL3313 | HNS-like transcriptional regulator | 3.70 |
BPSL0428 | Hypothetical protein | 34.00 |
BPSL1511 | Hypothetical protein | 4.08 |
BPSL2413 | Hypothetical protein | 13.12 |
The fold change represents the ratio of the number of sequence reads in the imipenem + spermine NONOate sample over spermine NONOate control.