Table 3. Selected clinical studies involving lung perfusate solutions. Euro-Collins vs. Perfadex/low potassium dextran solutions.
| Study | Solution | Cases | Patient survival | PaO2/FiO2 | Wean from ventilator |
|---|---|---|---|---|---|
| Aziz (8) | EC vs. PER | 69 (EC 37, PER 32) | No diff (30 d) (EC 89.2%, PER 90.7%; P=0.88) | No diff (EC 244 mmHg, PER 266 mmHg; P=0.9) | No diff (EC 71.2 hr, PER 81.9 hr; P=0.4) |
| Gámez (31) | EC vs. PER | 136 (EC 68, PER 68) | No diff (30 d) (EC 78, PER 80; P not listed) | No diff (EC 238 mmHg, PER 257 mmHg; P not listed) | No diff (EC 182 hr, PER 174 hr; P not listed) |
| Müller (32) | EC vs. PER | 80 (EC 48, 32 PER) | No diff (30 d) (EC 88%, PER 94%; P not listed) | – | No diff (EC 3 d, PER 4 d; P=0.67) |
| Rabanal (33) | EC vs. PER | 46 (EC 21, PER 25) | No diff (30 d) (EC 88%, PER 100%; P not stated) | PER > EC (PER 310 mmHg, EC 170 mmHg; P<0.05) | PER > EC (PER 72 hr, EC 92 hr; P<0.05) |
| Strüber (34) | EC vs. LPD | 106 (EC 63, LPD 57) | No diff (EC 86%, LPD 92%; P not listed) | No diff (EC 282 mmHg, LPD 303 mmHg; P not listed) | PER > EC (EC 321 hr, LPD 189 hr; P=0.006) |
| Fischer (35) | (EC vs. PER) + PGE1 | 94 (EC 46, PER 48) | No diff (EC 89.6%, PER 93.5%; P=0.082) | PER > EC (EC 310 mmHg, LPD 370 mmHg; P=0.017) | – |
Abbreviations: no diff, no statistically significant difference; PGE1, prostaglandin E1; EC, Euro-Collins; PER, Perfadex; LPD, low potassium dextran; d, day; hr, hours.