Table 5.

Sensitivity and specificity of tumor microenvironment of metastasis (TMEM) score and the TMEM composite score for various cutpoints in the estrogen receptor–positive/human epidermal growth factor receptor–negative subgroup.

Variable	Risk group	Cutpoint for risk group	Sensitivity (95% confidence interval)	Specificity (95% confidence interval)
TMEM score	Low risk	≤2	0.90 (0.87 to 0.93)	0.18 (0.14 to 0.22)
		≤4	0.85 (0.81 to 0.89)	0.30 (0.25 to 0.35)
		≤7	0.80 (0.75 to 0.85)	0.37 (0.31 to 0.43)
	High risk	≥29	0.46 (0.40 to 0.52)	0.80 (0.75 to 0.85)
		≥37	0.37 (0.31 to 0.43)	0.85 (0.81 to 0.89)
		≥50	0.26 (0.21 to 0.31)	0.91 (0.88 to 0.94)
Composite score	Low risk	≤−0.94	0.90 (0.85 to 0.95)	0.32 (0.24 to 0.39)
		≤−0.68	0.85 (0.79 to 0.91)	0.51 (0.43 to 0.59)
		≤−0.40	0.80 (0.74 to 0.87)	0.60 (0.52 to 0.68)
	High risk	≥0.00	0.69 (0.61 to 0.76)	0.80 (0.73 to 0.86)
		≥0.19	0.60 (0.52 to 0.68)	0.85 (0.79 to 0.91)
		≥0.70	0.43 (0.35 to 0.51)	0.90 (0.85 to 0.95)