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External genitalia of three adult female rats. (A) Vehicle control female. (B) 5.0 EE2-treated female. (C) 10.0 EE2-treated female. Genitalia of the EE2-treated females appear malformed and similar to what Sawaki et al. (see Figure 2 of Sawaki et al., 2003b) described as “excessive cleavage of urethral slit and insufficient raphe formation”.
