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. 2014 Aug 2;140(2):374–392. doi: 10.1093/toxsci/kfu077

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Published by Oxford University Press on behalf of Toxicological Sciences 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US

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FIG. 4. — Light and dark period residential running wheel activity (average number of wheel revolutions/12 h period) (mean ± SE). (A and B) Light period activity. *Pairwise comparisons of the significant interaction of treatment and sex indicated that females of the 5.0 and 10.0 EE₂ groups were significantly less active than vehicle control females. (C and D) Dark period activity. (*) Pairwise comparisons of the significant interaction of treatment and sex indicated that females of the 5.0 and 10.0 EE₂ groups were significantly less active than vehicle control females.