TABLE 4. Estrous Phase Proportions and Aberrant Transitions.
| Treatment | Proportion of days in each phase (mean ± SE) | % Extended estrus transitions | |||||
|---|---|---|---|---|---|---|---|
| Diestrus | Proestrus | Estrus | EX to EXb | EX to N | N to EX | Total | |
| Naïve control (n = 12) | 0.57 ± 0.03 | 0.22 ± 0.02 | 0.21 ± 0.03 | 0.72% | 1.44% | 1.44% | 3.60% |
| Vehicle control (n = 12) | 0.59 ± 0.04 | 0.18 ± 0.02 | 0.24 ± 0.04 | 3.54% | 0.39% | 0.79% | 4.72% |
| 2.5 BPA (n = 11) | 0.66 ± 0.04 | 0.16 ± 0.03 | 0.18 ± 0.03 | 0.00% | 0.42% | 0.42% | 0.84% |
| 25.0 BPA (n = 12) | 0.67 ± 0.03 | 0.17 ± 0.01 | 0.16 ± 0.02 | 0.00% | 0.00% | 0.00% | 0.00% |
| 5.0 EE2 (n = 5)a | 0.57 ± 0.07 | 0.18 ± 0.03 | 0.25 ± 0.07 | 0.93% | 3.74% | 4.67% | 9.34%† |
| 10.0 EE2 (n = 7)a | 0.34 ± 0.06* | 0.29 ± 0.10 | 0.37 ± 0.09 | 8.78% | 6.76% | 9.46% | 25.00%† |
aNot all females in the EE2 groups experienced vaginal opening, thus, the number of subjects in these groups is less.
bEX to EX indicates a transition from extended estrus to extended estrus; N to EX indicates a transition from normal to extended estrus.
*Significantly less than vehicle control group.
†Significantly more than vehicle control group.