TABLE 5. Parameters Modeled from Residential Running Wheel Activity Dataset (Mean ± SE).

	Naïve control	Vehicle control	2.5 BPA	25.0 BPA	5.0 EE2	10.0 EE2
Males
Initial amplitude	9.43 ± 2.57	2.57 ± 4.42	9.77 ± 4.49	4.21 ± 2.07	6.50 ± 4.10	18.87 ± 5.80
Daily increase in amplitude*	2.81 ± 0.46	4.99 ± 1.65	3.52 ± 1.18	4.31 ± 0.58	4.68 ± 1.79	1.96 ± 0.96
tmax†a	23.98 ± 0.32	23.33 ± 0.36	23.38 ± 0.49	24.22 ± 0.29	23.64 ± 0.27	24.52 ± 0.46
Beta	3.87 ± 1.98	4.87 ± 2.58	4.48 ± 1.36	2.09 ± 0.16	4.12 ± 1.64	3.35 ± 1.22
t1/2 upb	19.87 ± 0.30	19.24 ± 0.37	19.34 ± 0.46	20.11 ± 0.28	19.53 ± 0.27	20.44 ± 0.47
t1/2 down#b	4.10 ± 0.33	3.42 ± 0.35	3.43 ± 0.51	4.33 ± 0.29	3.75 ± 0.27	4.61 ± 0.46
Maximum activity	8.23 ± 0.04	8.18 ± 0.04	8.08 ± 0.10	8.22 ± 0.04	8.22 ± 0.06	8.17 ± 0.09
Minimum activity	15.77 ± 0.04	15.82 ± 0.04	15.92 ± 0.10	15.78 ± 0.04	15.78 ± 0.06	15.83 ± 0.09
Females
Initial amplitude	10.99 ± 9.30	7.39 ± 10.22	15.21 ± 11.25	5.90 ± 6.32	6.38 ± 6.76	13.22 ± 5.34
Daily increase in amplitudea	20.57 ± 2.66	20.54 ± 3.19	21.75 ± 2.69	17.13 ± 1.92	13.18 ± 2.64	6.63 ± 1.94
tmax	24.69 ± 0.46	24.97 ± 0.53	24.65 ± 0.53	24.95 ± 0.45	23.76 ± 0.34	24.58 ± 0.47
Beta	2.90 ± 0.83	1.97 ± 0.14	1.94 ± 0.14	6.52 ± 4.82	6.99 ± 4.05	7.55 ± 3.71
t1/2 up	20.55 ± 0.49	18.87 ± 1.62	20.53 ± 0.53	20.83 ± 0.45	19.63 ± 0.34	20.46 ± 0.48
t1/2 down	4.84 ± 0.44	5.07 ± 0.51	4.76 ± 0.53	5.06 ± 0.45	3.90 ± 0.34	4.71 ± 0.46
Maximum activity	8.29 ± 0.16	8.20 ± 0.05	8.23 ± 0.02	8.23 ± 0.04	8.27 ± 0.05	8.25 ± 0.08
Minimum activity	15.71 ± 0.16	15.80 ± 0.05	15.77 ± 0.02	15.77 ± 0.04	15.73 ± 0.05	15.75 ± 0.08

^at_max was estimated as the time of day, on a 24-h clock, at which maximum activity occurred. The value, 24, was added to postmidnight t_max estimates to enable averaging with premidnight times. For example, a mean t_max = 24.5 is 30 min after midnight.

^bt_{1/2 up} and t_{1/2 down} are estimated as the time of day, on a 24-h clock, at which half of the maximum activity was achieved, respectively, as activity increased or decreased.

*Significantly less for males relative to females (p < 0.001) and significantly less in the 5.0 and 10.0 EE2 groups (p < 0.050).

^†Significantly earlier for males relative to females (p < 0.002).

^#Significantly earlier for males relative to females (p < 0.001).